6-Bromo-2-Naphthol

6-Bromo-2-Naphthol (CAS No. 15231-91-1) is an organic compound with the chemical formula C10H7BrO. It is a derivative of naphthol, where a bromine atom is substituted at the 6th position of the naphthalene ring. This compound is a white to light brown crystalline solid and is widely used in chemical synthesis, particularly in the production of dyes, pigments, and pharmaceuticals. Below is a detailed overview of its properties, uses, and safety considerations.

Chemical Properties

6-Bromo-2-Naphthol has a molecular weight of 223.07 g/mol. It is sparingly soluble in water but soluble in organic solvents such as ethanol, methanol, and acetone. The presence of the hydroxyl group (-OH) and bromine atom makes it a reactive compound, suitable for various chemical reactions, including electrophilic substitution and coupling reactions.

Uses of 6-Bromo-2-Naphthol

1. Dye and Pigment Industry:
   • 6-Bromo-2-Naphthol is a key intermediate in the synthesis of azo dyes and pigments. These dyes are widely used in the textile, paper, and printing industries due to their vibrant colors and stability.
   • It is also used in the production of naphthol AS series dyes, which are used for dyeing cellulose fibers.
2. Pharmaceutical Industry:
   • The compound is used as an intermediate in the synthesis of pharmaceutical compounds, including anti-inflammatory drugs and other bioactive molecules.
3. Chemical Research:
   • 6-Bromo-2-Naphthol is used in chemical research as a reagent for organic synthesis and analytical studies. It is particularly useful in coupling reactions and as a building block for complex organic molecules.
4. Photographic Industry:
   • The compound is used in the production of photographic chemicals and developers.
5. Agrochemicals:
   • It serves as an intermediate in the synthesis of certain agrochemicals, such as herbicides and pesticides.

Safety and Handling

6-Bromo-2-Naphthol is a hazardous chemical and requires careful handling. Key safety considerations include:

1. Health Hazards:
   • Inhalation: Inhalation of dust or fumes can cause respiratory irritation and other health issues.
   • Ingestion: Accidental ingestion can lead to gastrointestinal irritation and systemic toxicity.
   • Skin Contact: Prolonged or repeated skin contact can cause irritation and dermatitis.
   • Eye Contact: Exposure to the eyes can cause irritation and damage.
2. Environmental Hazards:
   • The compound is toxic to aquatic life and can cause environmental damage if not disposed of properly.
3. Personal Protective Equipment (PPE):
   • When handling 6-Bromo-2-Naphthol, workers must wear appropriate PPE, including gloves, goggles, and lab coats. Respirators may be required in areas with poor ventilation.
4. Storage and Disposal:
   • The compound should be stored in a cool, dry place, away from incompatible materials such as strong oxidizers. Waste containing 6-Bromo-2-Naphthol must be disposed of in accordance with local and international hazardous waste regulations.

Regulatory Status

6-Bromo-2-Naphthol is regulated under various safety and environmental guidelines to ensure its safe use in industrial and laboratory settings. It complies with regulations such as the Toxic Substances Control Act (TSCA) in the United States and REACH (Registration, Evaluation, Authorisation, and Restriction of Chemicals) in the European Union.

Conclusion

6-Bromo-2-Naphthol (CAS No. 15231-91-1) is a versatile chemical compound with significant applications in the dye, pharmaceutical, and chemical industries. Its role as an intermediate in the synthesis of dyes, pharmaceuticals, and agrochemicals highlights its importance in modern manufacturing processes. However, due to its toxicity and environmental hazards, proper safety measures must be followed to ensure its safe handling and use. As industries continue to prioritize safety and sustainability, the use of 6-Bromo-2-Naphthol is expected to remain essential, with a focus on minimizing risks and environmental impact.